COCAINE

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…most people can consume a fairly high dose of cocaine with out serious harm, even a low dose can be dangerous for people with preexisting central nervous system or cardiac abnormalities (Isner et al., 1986; Mittleman and Wetli, 1987). People with enzyme deficiencies that interfere with cocaine's biotransformation may also be at higher risk (Devenyi, 1989). There is recent evidence that consuming alcohol with cocaine may be risky, especially for persons with heightened sensitivity to cocaine's effects (Karch, 1992).[23]