Guilt has a large part in manipulating how Macbeth and his wife act after they have committed their crimes. It is their guilt that drives them both mad. Before they have even killed Duncan, Macbeth feels guilty and considers backing out of the murder, but Lady Macbeth won't let him. Once again Macbeth sees that what he is doing is morally wrong, but he doesn't let that stop him. He kills the king despite his reservations.
Macbeth begins hearing things as soon as the murder …showed first 85 words of 363 total…
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…showed last 85 words of 363 total…hands. This routine and her sleep talking are signs and proof of her guilt. Malcolm and the thanes who have sided with him have heard that Macbeth is going mad, and they assume that his madness is a result of the guilt for his crimes. Lady Macbeth has commited suicide and her guilt is believed to be the cause of her death. Her conscience got the better of her in the end. Macbeth feels that if he continues to kill, he will eventually become king
