Ehlers-Danlos Syndrome

Importance Of the different types if Ehlers-Danlos syndrome, type IV is associated with an increased risk of death. Ehlers–Danlos type IV syndrome (EDS) is a heterogeneous group of inheritable connective tissue disorders, characterized by joint hyper-mobility, skin extensibility and tissue fragility. EDS results from the molecular abnormality of the connective tissues, and the clinical and genetic heterogeneity are in part, a reflection of an underlying biochemical heterogeneity (Pope, 1997). EDS is an autosomal dominant disorder …

…ruptures while a small percentage were the result of bowel ruptures. Pregnancy complications in women with EDS type IV are common. Women with EDS type IV have an increased risk of complications during pregnancy as well as a 50% risk of having an affected child. Even if all considerations are taken during pregnancy, the maternity mortality rate has risen 25% in cases involving EDS due to ruptures of artery, bowels and/or uterus during the pregnancy (Khalid, 2000).