Aerodynamic particle size analysis of a metered dose inhalation containing 100μg salbutamol sulphate in a single dose

The product being tested is a salamol CFC-free Easi-Breathe inhaler Each actuation of the inhaler delivers Salbutamol Sulphate Ph Eur equivalent to Salbutamol 100 micrograms into the mouthpiece of the adapter. Salbutamol is a selective β2-adrenoceptor agonist. At therapeutic doses it acts on the β2-adrenoceptors of bronchial smooth muscle providing short acting (4-6 hour) bronchodilatation with a fast onset (within 5 minutes) in reversible airways obstruction. Salamol is indicated in the management of bronchial asthma, …

…respirable lungs. Therefore according to this MMAD value a majority of the particles are able to reach respirable regions. This was illustrated by the fact that very particles were present on the first three plates (0,1,2) References *<Tab/>www.medicines.org *<Tab/>Aulton, M.E., 2002. Pharmaceutics "The Science Of Dosage Form Design" Second Edition. Churchill Livingstone, pp.476-485. *<Tab/>Dr Paul Carter, 2003 lecture support