Cell Biology Notes Alzheimers disease.

Alzheimer's disease 1) Primary Source - "FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a y-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the y-Secretase Cleavage Complex" Alzheimer's disease (AD) causes mutations in presenilin-1 (PS1) and presenilin -2 (PS2) that increase the formation of amyloid B-peptides (AB). AB is formed by increasing the cleavage of B-amyloid precursor protein (APP), and the cleavage of APP is performed by y-secretase. So in simpler …

…studies have been performed to show the effect of Ibuprofen. Mice were modified to carry gene that causes AD, they developed plaques, and upon receiving ibuprofen there was a decrease in brain inflammation. When compared to the untreated mice, the treated mice had half the number of plaques and half the total amount of brain amyloid. A similar study on deceased elderly people showed that those who used NSAIDs showed less amyloid on the brain