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Integrins

Date Submitted: 05/03/2000 02:00:07
Length: 9 pages (2361 words)
Views: 140797

Introduction Integrins are a large family of homologous transmembrane linker proteins that include collagen, fibronectin and laminin. They are a family of cell-surface proteins that mediated cell adhesion, a process that is essential for anchorage, and act as cues for cell migration and signals for growth and differentaition.1 In addition to their biological importance to fundamental cellular processes, integrins play a part in immune function, tissue repair, tumour invasion, and platelet aggregation.2 The integrins are …

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…R.M., Kopf G.S. Characterization of the binding of recombinant mouse sperm fertilin a subunit to mouse eggs: evidence for function as a cell adhesion molecule in sperm-egg binding. Develop. Biology, 187, 94-106 (1997) 11. Alon R., Kassner P., Carr M., Finger E.B., Hemler M.A., Springer T.A. Lymphocyte VLA-4 can mediate cell tethering, rolling and firm adhesions on VCAM-1 under flow. Cell. Biology. 128, 1243-1253. (1995) 12. Lodish., Berk., Zipursky., Matsudaira., Baltimore., Darnell. Molecular Cell Biology. 22, 968-1002

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