Retinoblastoma

The retinoblastoma families of proteins are key cell cycle regulatory molecules important for the differentiation of various mammalian cell types. The retinoblastoma protein (RB) regulates transcription of a variety of genes either by blocking the activation domain of various activators or by active repression (finding of appropriate promoters). If the RB?s function is lost, it will lead to a variety of cancers and defects in the development of certain cell types. Phosphorylation of RB …

…with the N-terminal. These receptors are significant, to an extent that concludes further studies must be conducted on towards the N-terminal. The main role of the N-terminal is still an uncertainty. Their role in binding with RB is anonymity. No factors that might bind RB solely with the N-terminal domain, but it is clear that the total structural information of the domain determines its efficacy because the entire N-terminal domain is necessary. (Puga et al, 2000)