Zofran: Applications in Medicine as a Serotonin Blocker

Chemotherapy induced nausea and vomiting, CINV, has been a significant problem with oncology patients over past years. As a result much research was done and has lead to the creation of Zofran (Bernstein and Ong 2002). Ondansetron, marketed as Zofran was the first of its kind; it is a serotonin 5-HT3 receptor blocker, otherwise know as an antiemetic agent. Ondansetron is a tremendous breakthrough and is much more effective than older antiemetics, in some cases by …

…alcoholism is also related to serotonin levels shows that ondansetron does in fact neutralize the serotonin receptors to help control many things, including vomiting. Zofran is a good example of the fact that doctors don't always use a drug for it FDA approved uses, in this case it FDA approved us is for the treatment of nausea and vomiting in cancer patients, but it is also being used to treat things as dissimilar as alcoholism.